Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease

C. Watts; Tim Donovan; Jonathan H. Gillard; N.M. Antoun; Rowan M. Burnstein; David K. Menon; T. Adrian Carpenter; Tim Fryer; D.G. Thomas; John D. Pickard

doi:10.3727/000000003108747316

Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease

C. Watts
, Tim Donovan
, Jonathan H. Gillard
, N.M. Antoun
, Rowan M. Burnstein
, David K. Menon
, T. Adrian Carpenter
, Tim Fryer
, D.G. Thomas
, John D. Pickard

University of Cumbria

Research output: Contribution to journal › Journal Article › peer-review

Abstract

The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington's disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible.

Original language	English
Pages (from-to)	697-704
Journal	Cell Transplantation
Volume	12
DOIs	https://doi.org/10.3727/000000003108747316
Publication status	Published - 1 Oct 2003

Keywords

brain
brain tissue transplantation
cell transplantation
fetal tissue transplantation
humans
huntington disease
magnetic resonance imaging
n eostriatum

Access to Document

10.3727/000000003108747316

https://doi.org/10.3727/000000003108747316

Cite this

@article{7c070b1536a042ed9c821ffa28bc637e,

title = "Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease",

abstract = "The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington's disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible.",

keywords = "brain, brain tissue transplantation, cell transplantation, fetal tissue transplantation, humans, huntington disease, magnetic resonance imaging, n eostriatum",

author = "C. Watts and Tim Donovan and Gillard, \{Jonathan H.\} and N.M. Antoun and Burnstein, \{Rowan M.\} and Menon, \{David K.\} and Carpenter, \{T. Adrian\} and Tim Fryer and D.G. Thomas and Pickard, \{John D.\}",

year = "2003",

month = oct,

day = "1",

doi = "10.3727/000000003108747316",

language = "English",

volume = "12",

pages = "697--704",

journal = "Cell Transplantation",

issn = "0963-6897",

publisher = "SAGE Publications Inc.",

}

TY - JOUR

T1 - Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease

AU - Watts, C.

AU - Donovan, Tim

AU - Gillard, Jonathan H.

AU - Antoun, N.M.

AU - Burnstein, Rowan M.

AU - Menon, David K.

AU - Carpenter, T. Adrian

AU - Fryer, Tim

AU - Thomas, D.G.

AU - Pickard, John D.

PY - 2003/10/1

Y1 - 2003/10/1

N2 - The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington's disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible.

AB - The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington's disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible.

KW - brain

KW - brain tissue transplantation

KW - cell transplantation

KW - fetal tissue transplantation

KW - humans

KW - huntington disease

KW - magnetic resonance imaging

KW - n eostriatum

U2 - 10.3727/000000003108747316

DO - 10.3727/000000003108747316

M3 - Journal Article

SN - 0963-6897

VL - 12

SP - 697

EP - 704

JO - Cell Transplantation

JF - Cell Transplantation

ER -

Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this